Vitamin D deficiency increases the activity of B cells in patients with multiple sclerosis (MS), according to a new study. The finding supports the hypothesis that vitamin D supplementation might have a disease modifying role in the treatment of MS. The researchers conclude that the effects of vitamin D deficiency in B cells exacerbate disease activity, indicating that the ongoing trials of vitamin D supplementation should demonstrate therapeutic effects. For more info like this you can visit http://cancergnosis.com/
B cells play at the central role in multiple sclerosis. They are involved in the activation of pro-inflammatory T cells, secretion of pro-inflammatory cytokines and the production of antibodies directed against myelin.
Many studies have established that low vitamin D levels are a risk factor for MS, but the exact nature of the effect is unclear. “Available data suggest that vitamin D in sufficient concentrations decreases the activity of immune cells, including T cells,” explains Jürgen Haas, lead author of the new study. “The role of B cells in MS has been emphasized by the therapeutic efficacy of antibodies against B cells, but data on the interaction between B cells and vitamin D are scarce.”
The researchers studied this interaction in 95 patients with relapsing-remitting MS, nearly half of whom had vitamin D deficiency – a level serum metabolite 25-hydroxyvitamin D (25 (OH) D) below 20 nanograms / ml. Measurements 25 (OH) D in the blood and cerebrospinal fluid (CSF) of patients with experiments were combined in vitro in cells to evaluate the effects of vitamin D in B cell immunoreactivity
The B cells isolated from 28 patients with MS showed greater proliferation and release of interleukin-6 (IL-6) in response to immunostimulatory B cells from healthy controls or other disorders. Immunoreactivity was particularly high in the cells of MS patients with vitamin D deficiency
Incubation of B cells isolated at different concentrations of the active metabolite of vitamin D showed immunoreactivity was dose – dependent. The MS patients and deficit vitmamina D had more frequent higher scores and relapse patients with MS enough vitamin D, which indicates a more serious illness.
In 12 patients with B cell function was assessed before and after taking vitamin D supplements, the proliferative response of B cells and release of IL-6 was reduced after supplementation.
The study also showed that vitamin D deficiency results in effects on the central nervous system (CNS). “Patients with low levels of vitamin D showed a decrease vitamin D levels in the cerebrospinal fluid (CSF) and increased intrathecal antibody secretion of B memory cells with class switching and plasma cells secreting antibodies,” says Haas. “These data support the hypothesis that vitamin D deficiency in the blood and CSF interact to negatively interfere with the immune response inside and outside the CNS.”