Blows to the head break neurons

The blows to the head, in addition to causing local inflammation, can take its toll in the long term, especially if they occur during adolescence, when the brain is still “under construction”. In 2014, a study published in “American Journal of Psychiatry” held that a single lesion raises the risk for mental disorders such as schizophrenia (65% more) or depression (59%) up to fifteen years after the trauma. In addition, heavy blows can break the impermeability of the blood – brain barrier, a sort of customs that protects the brain from what comes through the circulatory system. To know more you can also like to visit http://www.bringbackplay.mobi/

blows-to-the-head-break-neuronsLast year, another investigation of Beth Israel Deaconess Medical Center in Boston, conducted on mice, published the journal “Nature” provided the first direct evidence linking traumatic brain injury with chronic traumatic encephalopathy and Alzheimer’s disease .

Now new research, this time from Brown University, has been able to see in real time what happens to neurons after experiencing the kind of forces involved in a blow to the head.

In the National American Football League, for example, the impacts on the heads of the players are from about 15 milliseconds, but it is unclear how that wave energy is transmitted through the brain. Strain rate applied to the outside of the head could be very different from that transmitted through the brain, and this study suggests that the manifestation of the lesion could be different depending on the strain rate.

With speeds higher strain used in the study, neurons develop axonal injury diffuse characteristic of traumatic brain injury. It is that the axons of neurons swell and eventually breaks, forming bubbles or “blisters” in the breakpoints. But a slower deformation, structural damage was different. Instead of rupture and form blisters, axons and dendrites contract as the cells die.

The study has been carried out by designing a special device that allows you to compress neurons in cell culture in 3-D. The device has a hydraulic piston located at the top of a confocal laser-scanning microscope. The piston fits accurately the compressive force to which subjects the cells, while the continuous images generated microscope s cellular structures. That could be conducted observation in real time what happens to neurons when they experience such forces that cause a blow to the head.

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